Abstract |
The aim of this study was to test the efficacy of low doses of pamidronate in increasing bone mineral density (BMD) in non-ambulatory children and adolescents with cerebral palsy (CP). Twenty-three non-ambulatory children and adolescents (12 females, 11 males; mean age 10y [SD 5y], range 4y 1 mo-17 y 11 mo) with severe spastic quadriplegic CP and low BMD were recruited from a multidisciplinary clinic. Severity of CP was graded at Level IV (n=10) and Level V (n=13) using the Gross Motor Function Classification System. Patients received intravenous pamidronate (4.12 mg/kg/y, maximum 45 mg/d) every 4 months. Lumbar spine and femoral neck BMD were measured at baseline and after 4 and 12 months. Twelve months after the first dose of pamidronate there was a significant increase in lumbar spine and femoral neck BMD (p<0.01 for both sites) and z scores compared with baseline values (p<0.01 for both sites). Mean BMD z scores increased 1.6 points for femoral neck and 1.9 points for lumbar spine after 12 months of pamidronate treatment. Serum intact parathyroid hormone increased significantly and cross-linked N-teleopeptide of type I collagen decreased significantly at 12 months. No significant side effect was noted. Low doses of pamidronate are well tolerated and significantly increase BMD in non-ambulatory children and adolescents with CP.
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Authors | Horacio Plotkin, Susan Coughlin, Rose Kreikemeier, Kathryn Heldt, Matias Bruzoni, Gary Lerner |
Journal | Developmental medicine and child neurology
(Dev Med Child Neurol)
Vol. 48
Issue 9
Pg. 709-12
(Sep 2006)
ISSN: 0012-1622 [Print] England |
PMID | 16904014
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Pamidronate
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Topics |
- Adolescent
- Bone Density
(drug effects)
- Bone Density Conservation Agents
(administration & dosage)
- Bone Diseases, Metabolic
(drug therapy, etiology)
- Cerebral Palsy
(complications, drug therapy)
- Child
- Child, Preschool
- Diphosphonates
(administration & dosage)
- Disabled Children
- Dose-Response Relationship, Drug
- Female
- Fractures, Bone
(etiology, prevention & control)
- Humans
- Infusions, Intravenous
- Male
- Mobility Limitation
- Pamidronate
- Pilot Projects
- Severity of Illness Index
- Treatment Outcome
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