Abstract |
Heterotopic bone formation caused by urothelial carcinoma is rare. The precise mechanism of heterotopic ossification is still unknown. We report a case of urothelial carcinoma with heterotopic bone formation in a metastatic site and investigate the expression of bone morphogenetic protein 2 (BMP-2) and the BMP receptor (BMPR)-Ib using immunohistochemistry. Positive staining of BMP-2 was observed in the cytoplasm of tumor cells in both bladder and psoas lesions. In addition, positive staining of BMPR-Ib was seen in osteoblast-like cells adjacent to bone formation in the psoas metastasis. The heterotopic ossification may result from the metaplasia of pluripotent stem cells into osteoblast cells induced by BMP-2 in a paracrine fashion.
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Authors | Yoshinobu Komai, Shinji Morimoto, Kazutaka Saito, Masayasu Urushibara, Kunihiko Sakai, Satoshi Ikeda |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 13
Issue 8
Pg. 1126-8
(Aug 2006)
ISSN: 0919-8172 [Print] Australia |
PMID | 16903944
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- BMP2 protein, human
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins
- Transforming Growth Factor beta
- Bone Morphogenetic Protein Receptors, Type I
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Topics |
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein Receptors, Type I
(metabolism)
- Bone Morphogenetic Proteins
(metabolism)
- Carcinoma
(diagnosis, metabolism, secondary, surgery)
- Fatal Outcome
- Humans
- Immunohistochemistry
- Male
- Metaplasia
- Middle Aged
- Muscle Neoplasms
(diagnosis, metabolism, secondary, surgery)
- Ossification, Heterotopic
(etiology, metabolism)
- Osteoblasts
- Pluripotent Stem Cells
(pathology)
- Psoas Muscles
- Stromal Cells
- Transforming Growth Factor beta
(metabolism)
- Urinary Bladder Neoplasms
(diagnosis, metabolism, pathology, surgery)
- Urothelium
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