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The discovery of CCR5 receptor antagonists for the treatment of HIV infection: hit-to-lead studies.

AuthorsDuncan Armour, Marcel J de Groot, Martin Edwards, Manos Perros, David A Price, Blanda L Stammen, Anthony Wood
JournalChemMedChem (ChemMedChem) Vol. 1 Issue 7 Pg. 706-9 (Jul 2006) ISSN: 1860-7179 [Print] Germany
PMID16902922 (Publication Type: Journal Article)
Chemical References
  • Anti-HIV Agents
  • Benzimidazoles
  • CCR5 Receptor Antagonists
  • Cyclobutanes
  • UK-374503
Topics
  • Anti-HIV Agents (chemical synthesis, chemistry, pharmacology)
  • Benzimidazoles (chemical synthesis, chemistry, pharmacology)
  • CCR5 Receptor Antagonists
  • Cyclobutanes (chemical synthesis, chemistry, pharmacology)
  • HIV Infections (drug therapy)
  • Humans
  • Inhibitory Concentration 50
  • Structure-Activity Relationship

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