[Studies on renal dysfunction after intra-arterial hypertensive chemotherapy (CDDP, PEP) for advanced cancer of the uterine cervix--serum.urinary alpha 1-microglobulin, beta 2-microglobulin and urinary lysozyme, albumin].

Abstract

The present study evaluated the degree of renal impairment caused by intra-arterial hypertensive chemotherapy (CDDP, PEP). In 11 cases of advanced cancer of the uterine cervix, serum and urinary levels of alpha 1-microglobulin (alpha 1-m) and beta 2-microglobulin (beta 2-m), and urinary albumin (Alb) and lysozyme (LZM) were determined before the chemotherapy and 1,2 and 3 weeks after the therapy. Results are summarized as follows: 1. After intra-arterial chemotherapy, the histological classification was Grade I in 1 case (9.1%), Grade IIa in 2 cases (18.2%), and Grade IIb in 8 cases (72.7%). 2. Serum alpha 1-m and beta 2-m levels remained within the normal range after chemotherapy. 3. Urinary alpha 1-m, beta 2-m and LZM levels exceeded the normal limit between 1 and 2 weeks after the therapy, but thereafter they returned to normal. 4. Urinary Alb was significantly increased (p less than 0.05) between 1 and 2 weeks after therapy, but thereafter it returned to normal. These results suggested that intra-arterial chemotherapy (CDDP 100mg and PEP 40 mg in a dose) was effective for advanced cancer of the cervix and that renal disorders including tubular and glomerular impairment, which are the adverse effects of the therapy, were mild and reversible.

• Authors: O Iwanari, Y Date, N Yoshino, J Miyako, K Ryuhkoh, M Moriyama, S Nakayama, M Kitao
• Journal: Nihon Sanka Fujinka Gakkai zasshi (Nihon Sanka Fujinka Gakkai Zasshi) Vol. 42 Issue 2 Pg. 115-20 (Feb 1990) ISSN: 0300-9165 [Print] Japan
• PMID: 1690251 (Publication Type: English Abstract, Journal Article)

Chemical References

• Alpha-Globulins
• alpha-1-microglobulin
• beta 2-Microglobulin
• Bleomycin
• Angiotensin II
• Peplomycin
• Muramidase
• Cisplatin

Topics

• Adult
• Aged
• Albuminuria (chemically induced, urine)
• Alpha-Globulins (metabolism, urine)
• Angiotensin II (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects, therapeutic use)
• Bleomycin (administration & dosage, adverse effects)
• Blood Pressure (drug effects)
• Carcinoma, Squamous Cell (drug therapy, metabolism, physiopathology)
• Cisplatin (administration & dosage, adverse effects)
• Female
• Humans
• Infusions, Intra-Arterial
• Kidney (drug effects, physiopathology)
• Middle Aged
• Muramidase (urine)
• Peplomycin
• Uterine Cervical Neoplasms (drug therapy, metabolism, physiopathology)
• beta 2-Microglobulin (metabolism, urine)