[Analysis of the local synthesis of Toxoplasma gondii-specific immunoglobulins in the anterior eye chamber fluid. Report of two cases].

Abstract

We reported two cases strongly suspected of ocular toxoplasmosis, in which a puncture of anterior eye chamber was performed for a final verification of clinical diagnosis. In both patients, fresh focal lesions of retinochoroiditis associated with old pigmented retinal scars were diagnosed. The 62-year-old women had a serological evidence of recently acquired T. gondii infection with an increasing IgG titre of a low avidity and a presence of specific IgM and IgA antibodies. In the 13-year-old girl, an immunological profile of the chronic infection was shown, confirmed by a high IgG avidity value. In the patient with a clinical picture of recurrent congenital toxoplasmosis, intraocular production of T. gondii-specific IgG was found in anterior eye chamber. The analysis of the specific antibodies synthesis in ocular fluid by the Western blot seems to be a valuable immunodiagnostic method for a final diagnosis of ocular toxoplasmosis.

• Authors: M Paul, J Stefaniak, K Pecold, H Twardosz-Pawlik, E Kacprzak, W Rychlicki
• Journal: Wiadomosci parazytologiczne (Wiad Parazytol) Vol. 47 Suppl 1 Pg. 33-8 ( 2001) ISSN: 0043-5163 [Print] Poland
• Vernacular Title: Analiza lokalnej syntezy swoistych immunoglobulin przeciwko Toxoplasma gondii w płynie z przedniej komory oka. Opis 2 przypadków.
• PMID: 16897949 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Protozoan
• Immunoglobulins

Topics

• Adolescent
• Animals
• Antibodies, Protozoan (analysis)
• Aqueous Humor (immunology, parasitology)
• Chorioretinitis (diagnosis, parasitology)
• Female
• Humans
• Immunoglobulins (analysis)
• Middle Aged
• Recurrence
• Serologic Tests
• Toxoplasma (isolation & purification)
• Toxoplasmosis, Congenital (diagnosis, parasitology)
• Toxoplasmosis, Ocular (diagnosis, parasitology)