Abstract | INTRODUCTION:
Teriparatide [rhPTH (1-34)] reduces fracture risk, and in a published meta-analysis of clinical trials, teriparatide-treated patients had reduced incidence of back pain relative to placebo or to antiresorptive drugs. The aim of this study was to evaluate back pain in teriparatide-treated versus comparator-treated patients during an interval including controlled clinical trials plus 30 months of additional follow-up. METHODS: A meta-analysis of four completed randomized, double-blinded trials of teriparatide [rhPTH (1-34)] versus comparator was performed. A multivariate Cox proportional hazards model was used to assess the heterogeneity of results and to estimate the relative risk of back pain. RESULTS: Patients in the pooled teriparatide group had reduced risk for any back pain [relative risk, 0.73 (95% CI, 0.61-0.87)], moderate or severe back pain [0.72 (0.58-0.89)], and severe back pain [0.39 (0.25-0.61)] compared with pooled controls, from initiation of the study drug through the end of follow-up. Sensitivity analysis showed that the results were robust to the removal of each individual trial from the meta-analysis. Separate meta-analyses comparing teriparatide versus placebo or antiresorptive drugs gave similar results. CONCLUSIONS:
Teriparatide-treated patients had a reduced incidence of back pain versus those receiving a comparator during an observation encompassing clinical trials plus 30 months of posttreatment observation.
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Authors | M C Nevitt, P Chen, D P Kiel, J-Y Reginster, R K Dore, J R Zanchetta, E V Glass, J H Krege |
Journal | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
(Osteoporos Int)
Vol. 17
Issue 11
Pg. 1630-7
( 2006)
ISSN: 0937-941X [Print] England |
PMID | 16896507
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bone Density Conservation Agents
- Teriparatide
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Topics |
- Back Pain
(etiology, prevention & control)
- Bone Density Conservation Agents
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Osteoporosis
(complications, drug therapy)
- Randomized Controlled Trials as Topic
- Spinal Fractures
(etiology, prevention & control)
- Teriparatide
(therapeutic use)
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