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T cell mediated immune responses in patients with tuberculous lymphadenitis from Butajira, southern Ethiopia.

Abstract
The control of tuberculosis (TB) requires improved vaccines in addition to chemotherapy. It is essential to understand the immune response in tuberculosis to successfully evaluate potential vaccines. Current investigations have focused on immune responses in pulmonary forms. We studied the T-cell response of peripheral blood mononuclear cells (PBMC) from HIV-infected (n=8) and non-infected patients (n=19) with lymph node tuberculosis to PPD and short-term culture filtrates (ST-CF) of M. tuberculosis. PBMC from HIV-negative TB lymphadenitis patients proliferated in response to both antigens (p<0.001) and produced variably higher levels of IFN-gamma compared to healthy controls (p=0.02) (n=19) from the same area. Such responses were suppressed in HIV co-infected subjects. The results indicate that circulating PBMC in the apparently localized form of tuberculous lymphadenitis react to mycobacterial antigens in a similar pattern as those of patients with pulmonary disease.
AuthorsAbebe Habte, Mulu Geletu, Joseph Okao Olobo, Dawit Kidane, Yohannes Negesse, Mohammed Ahmed Yassin, Bereda Kifle, Getahun Abate, Morten Harboe, Abraham Aseff
JournalEthiopian medical journal (Ethiop Med J) Vol. 42 Suppl 1 Pg. 29-35 (Apr 2004) ISSN: 0014-1755 [Print] Ethiopia
PMID16895017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Bacterial
  • Interferon-gamma
Topics
  • Adult
  • Antigens, Bacterial (analysis, immunology)
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Ethiopia
  • HIV Infections (complications, immunology)
  • Humans
  • Immunity, Cellular
  • Interferon-gamma (biosynthesis)
  • T-Lymphocytes (immunology)
  • Tuberculosis, Lymph Node (complications, immunology)

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