Different effects of tibolone and low-dose EPT in the management of postmenopausal women with primary headaches.

Abstract

OBJECTIVE:

The present randomized prospective study aimed to compare the effect of tibolone (T) with conventional low-dose estrogen-progestogen therapy (EPT) administered in a combined continuous regimen on the course of primary headaches in postmenopausal women requesting hormone therapy (HT) for climacteric complaints.

DESIGN:

Forty women presenting for clinical evaluation of headache (migraine without aura and episodic tension-type headache) were enrolled. The observational period lasted 7 months during which women kept a diary of the clinical characteristics of headache attacks and analgesic use. Climacteric symptoms and both anxiety and depression were also measured. After a 1-month run-in period, women received two different HT regimens: 1 mg 17beta-estradiol + 0.5 mg norethisterone acetate (EPT) or 2.5 mg T. Follow-up evaluations were planned after 3 and 6 months of treatment.

RESULTS:

Although T did not affect the number of days with migraine without aura, it significantly reduced the number of hours during which pain intensity prohibited daily activities (P < 0.001) and the number of analgesics (P < 0.001) after 3 months. Conventional low-dose EPT administered in a combined continuous regimen was confirmed to have a mild, but negative, effect on the course of migraine without aura by increasing the number of days with head pain (P < 0.001) and the number of analgesics (P < 0.001). Interestingly, both treatments were effective in the management of episodic tension-type headache, significantly reducing the number of days with head pain, severity, and analgesic consumption.

CONCLUSIONS:

In postmenopausal headache sufferers, analgesics are more effective in alleviating severe head pain when women are treated with T in comparison with low-dose EPT for climacteric complaints.

• Authors: Rossella E Nappi, Grazia Sances, Arianna Sommacal, Silvia Detaddei, Fabio Facchinetti, Silvano Cristina, Franco Polatti, Giuseppe Nappi
• Journal: Menopause (New York, N.Y.) (Menopause) 2006 Sep-Oct Vol. 13 Issue 5 Pg. 818-25 ISSN: 1072-3714 [Print] United States
• PMID: 16894336 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Estrogen Receptor Modulators
• Norpregnenes
• tibolone

Topics

• Analysis of Variance
• Estrogen Receptor Modulators (administration & dosage, pharmacology)
• Estrogen Replacement Therapy
• Female
• Headache (drug therapy)
• Humans
• Middle Aged
• Norpregnenes (administration & dosage, pharmacology)
• Postmenopause (drug effects)
• Prospective Studies