Deflazacort for type-1 autoimmune hepatitis in a Korean girl.

Abstract

Prednisone or prednisolone are the mainstay drug treatments for autoimmune hepatitis in children. However, long-term use of corticosteroid is associated with the risk of steroid-induced toxicities, and this situation requires newer immuno-suppressive agents for the treatment of autoimmune hepatitis, especially in growing children. An 11-yr-old Korean girl with type-1 autoimmune hepatitis discontinued prednisolone due to toxicities, i.e., hirsutism, buffalo hump, and skin striae, and remained clinical and biochemical remission under replacement of deflazacort and ursodeoxycholic acid combination therapy. A follow-up liver biopsy after 19 months of deflazacort and ursodeoxycholic acid treatment showed histologic remission.

• Authors: Sun Hwan Bae, Jae Seon Kim, Dong Hoon Kim
• Journal: Journal of Korean medical science (J Korean Med Sci) Vol. 21 Issue 4 Pg. 758-60 (Aug 2006) ISSN: 1011-8934 [Print] Korea (South)
• PMID: 16891827 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cholagogues and Choleretics
• Immunosuppressive Agents
• Pregnenediones
• Ursodeoxycholic Acid
• deflazacort

Topics

• Child
• Cholagogues and Choleretics (therapeutic use)
• Drug Therapy, Combination
• Female
• Hepatitis, Autoimmune (drug therapy)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Korea
• Pregnenediones (therapeutic use)
• Treatment Outcome
• Ursodeoxycholic Acid (therapeutic use)