Abstract | PURPOSE: MATERIALS AND METHODS: Urine specimens and completed O'Leary-Sant interstitial cystitis symptom and problem indexes questionnaires were obtained from 29 patients with interstitial cystitis, 14 normal individuals, and 14 patients with other benign pelvic and bladder conditions. Patients with interstitial cystitis were divided into group 1-1 or both indexes less than 50% maximum score, and group 2-both indexes 50% of maximum score or greater. All patients met the National Institutes of Diabetes and Digestive and Kidney Diseases criteria except regarding glomerulation. In a followup study 30 urine specimens were collected from 8 patients with interstitial cystitis and from 4 normal individuals during 12 months. The urinary glycosaminoglycan profile was determined by gel filtration chromatography. Glycosaminoglycan peaks were analyzed by polyacrylamide gel electrophoresis. Urinary hyaluronic acid levels were determined by the hyaluronic acid test. RESULTS: CONCLUSIONS:
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Authors | Vinata B Lokeshwar, Marie G Selzer, Darius J Unwala, Veronica Estrella, Maria-Fernanda Lorenzo Gomez, Roozbeh Golshani, Robert R Kester, David J Klumpp, Angelo E Gousse |
Journal | The Journal of urology
(J Urol)
Vol. 176
Issue 3
Pg. 1001-7
(Sep 2006)
ISSN: 0022-5347 [Print] United States |
PMID | 16890679
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycosaminoglycans
- Hyaluronic Acid
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cystitis, Interstitial
(urine)
- Female
- Glycosaminoglycans
(urine)
- Humans
- Hyaluronic Acid
(urine)
- Male
- Middle Aged
- Severity of Illness Index
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