[An autopsy case of obliterative bronchiolitis associated with Stevens-Johnson syndrome].

Abstract

We reviewed an autopsied 27-year-old female with obliterative bronchiolitis associated with Stevens-Johnson syndrome. She had a history of Stevens-Johnson syndrome at age 10 years old and was treated with corticosteroids. Two months after the onset of dermatitis, the patient complained of dyspnea on exertion. The chest radiograph showed hyperinflation, and pulmonary function tests revealed obstructive impairment. The respiratory failure progressed due to respiratory tract infection and pneumothorax. She underwent thoracoscopic cyst surgery for right pneumothorax. Although the patient was clinically diagnosed as having obliterative bronchiolitis and received corticosteroids therapy and mechanical ventilation, she died of progressive respiratory failure 17 years after the onset of Stevens-Johnson syndrome. On autopsy, the macroscopic appearance of both lungs showed multiple white nodules in the centrilobular lesion corresponding to the obliteration of the small bronchioli. The microscopic appearance revealed constrictive bronchiolitis in the membranous bronchioli of both lungs associated with secondary bronchiectasis caused by superimposed infection.

• Authors: Keishi Sugino, Kazuhiro Kimura, Go Sano, Nobuhide Kato, Keigo Takagi, Kayoko Tsuchiya, Akira Hebisawa, Koichiro Nakata
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 44 Issue 7 Pg. 511-6 (Jul 2006) ISSN: 1343-3490 [Print] Japan
• PMID: 16886808 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amoxicillin

Topics

• Adult
• Amoxicillin (adverse effects)
• Bronchiolitis Obliterans (diagnostic imaging, etiology, pathology)
• Fatal Outcome
• Female
• Humans
• Radiography, Thoracic
• Respiratory Insufficiency (etiology, pathology)
• Stevens-Johnson Syndrome (chemically induced, complications)