Intestinal antiinflammatory activity of a lyophilized infusion of Turnera ulmifolia in TNBS rat colitis.

Abstract	Turnera ulmifolia is a plant popularly known in Brazil and South America as chanana. Some species of Turnera are widely used in folk medicine for different types of inflammatory diseases. In this study, the preventive intestinal antiinflammatory activity of a lyophilized infusion obtained from the aerial parts of T. ulmifolia was tested in the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. The results obtained revealed that pretreatment to colitic rats with the extract, at 250 and 500 mg/kg, significantly attenuated the colonic damage induced by TNBS. This beneficial effect was associated with an improvement in the colonic oxidative status, since the infusion prevented the glutathione depletion that occurred as a consequence of the colonic inflammation. On the other hand, this antioxidant activity was confirmed in in vitro studies. In conclusion, the preventive effect exerted by the lyophilized infusion of T. ulmifolia in the TNBS model of rat colitis is probably related to its antioxidant properties, due to its flavonoids content.
Authors	Julio Galvez, Juliano de Souza Gracioso, Desirée Camuesco, Julio Galvez, Wagner Vilegas, Alba Regina Monteiro Souza Brito, Antonio Zarzuelo
Journal	Fitoterapia (Fitoterapia) Vol. 77 Issue 7-8 Pg. 515-20 (Dec 2006) ISSN: 0367-326X [Print] Netherlands
PMID	16876965 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Gastrointestinal Agents Plant Extracts Trinitrobenzenesulfonic Acid
Topics	Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, pharmacology, therapeutic use) Colitis (chemically induced, drug therapy, pathology) Disease Models, Animal Dose-Response Relationship, Drug Female Freeze Drying Gastrointestinal Agents (administration & dosage, pharmacology, therapeutic use) Phytotherapy Plant Components, Aerial Plant Extracts (administration & dosage, pharmacology, therapeutic use) Rats Rats, Wistar Trinitrobenzenesulfonic Acid Turnera

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