The significance of p53 and bcl-2 overexpression and other prognostic factors in transitional cell carcinoma of the bladder.

Abstract

The aim of this study was to investigate the expression of bcl-2 and p53 oncoproteins in a series of transitional cell bladder carcinomas and its relation to traditional prognostic indicators and patients' survival. Specimens from 59 patients who underwent transurethral resection from March 1992 to February 1997 were included in this study. Tumors were graded based on WHO grades 1-3 and staged according to the 1997 TNM classification. Three patients lost to follow-up were excluded from the analysis. We could not establish a statistically significant relation between bcl-2 and p53 and other parameters such as sex, age, stage and grade. Tumor grade and stage were the most important factors for predicting tumor recurrence and aggressiveness. Only sex seems to significantly affect the statistics of the risk of death (p<0.05). Women had quadruple risk of death compared to men.

• Authors: Stavros Touloupidis, Georgios Fatles, Christos Kalaitzis, Alexandra Giatromanolaki, Eythimyos Sivridis, Konstantinos Simopoulos, Vassilios Rombis
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 38 Issue 2 Pg. 231-6 ( 2006) ISSN: 0301-1623 [Print] Netherlands
• PMID: 16868688 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Proto-Oncogene Proteins c-bcl-2
• Tumor Suppressor Protein p53

Topics

• Age Factors
• Aged
• Antigens, Neoplasm (analysis)
• Carcinoma, Transitional Cell (diagnosis, mortality, surgery)
• Disease Progression
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Proportional Hazards Models
• Proto-Oncogene Proteins c-bcl-2 (analysis)
• Recurrence
• Sex Factors
• Survival Analysis
• Tumor Suppressor Protein p53 (analysis)
• Urinary Bladder Neoplasms (diagnosis, mortality, surgery)