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DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.

Abstract
In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.
AuthorsMichele Milanese, Ludovica Segat, Alessandra Pontillo, Luiz Claudio Arraes, José Luiz de Lima Filho, Sergio Crovella
JournalAIDS (London, England) (AIDS) Vol. 20 Issue 12 Pg. 1673-5 (Aug 01 2006) ISSN: 0269-9370 [Print] England
PMID16868452 (Publication Type: Journal Article)
Chemical References
  • Anti-Infective Agents
  • DEFB1 protein, human
  • Genetic Markers
  • beta-Defensins
Topics
  • Adolescent
  • Anti-Infective Agents
  • Brazil (epidemiology)
  • Child
  • Child, Preschool
  • Gene Frequency
  • Genetic Markers (genetics)
  • Genotype
  • HIV Infections (epidemiology, genetics)
  • HIV-1
  • Humans
  • Infant
  • Polymorphism, Single Nucleotide (genetics)
  • Risk Factors
  • beta-Defensins (genetics)

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