Abstract |
In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.
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Authors | Michele Milanese, Ludovica Segat, Alessandra Pontillo, Luiz Claudio Arraes, José Luiz de Lima Filho, Sergio Crovella |
Journal | AIDS (London, England)
(AIDS)
Vol. 20
Issue 12
Pg. 1673-5
(Aug 01 2006)
ISSN: 0269-9370 [Print] England |
PMID | 16868452
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- DEFB1 protein, human
- Genetic Markers
- beta-Defensins
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Topics |
- Adolescent
- Anti-Infective Agents
- Brazil
(epidemiology)
- Child
- Child, Preschool
- Gene Frequency
- Genetic Markers
(genetics)
- Genotype
- HIV Infections
(epidemiology, genetics)
- HIV-1
- Humans
- Infant
- Polymorphism, Single Nucleotide
(genetics)
- Risk Factors
- beta-Defensins
(genetics)
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