Abstract | BACKGROUND: AIM: To investigate the relations between circulating levels of 1,25( OH)2D and 25OHD respectively and parathyroid adenoma weight (AW), plasma- parathyroid hormone (P-PTH) and PTH secretion expressed as P-PTH/AW. DESIGN: Cross-sectional study. MATERIAL: One hundred and seventy-one consecutive hypercalcaemic caucasian patients aged 19-87 years (median 63, 84% females) with surgically proven parathyroid adenoma. RESULTS: A weak positive correlation was found between P-25OHD and P-1,25(OH)2D (r=0.24, P<0.005). AW depended on sex and body mass index. Following adjustment, it was correlated positively to P-PTH, calcium (Ca) and alkaline phosphatase (AP) and inversely to plasma phosphate in a multiple regression model. AW was not associated with vitamin D metabolites. Preoperative P-PTH correlated positively to plasma levels of Ca and AP, but inversely to phosphate and 25OHD (P<0.001) levels. P-PTH was not associated with P-1,25(OH)2D (P=0.65). The P-PTH:AW ratio correlated inversely to P-25OHD (P<0.05), but showed no relations to plasma levels of Ca, phosphate or 1,25( OH)2D (P=0.22). CONCLUSION: In this material, low levels of 25OHD were related to higher levels of P-PTH and higher PTH:AW ratios in patients with PHPT suggesting that vitamin D deficiency increase PTH secretion activity. Neither PTH secretion nor AW was associated with circulating levels of 1,25( OH)2D.
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Authors | B Moosgaard, P Vestergaard, L Heickendorff, F Melsen, P Christiansen, L Mosekilde |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 155
Issue 2
Pg. 237-44
(Aug 2006)
ISSN: 0804-4643 [Print] England |
PMID | 16868136
(Publication Type: Journal Article)
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Chemical References |
- Parathyroid Hormone
- Vitamin D
- 1,25-dihydroxyvitamin D
- 25-hydroxyvitamin D
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Topics |
- Adenoma
(blood, complications, pathology)
- Adult
- Aged
- Aged, 80 and over
- Cross-Sectional Studies
- Female
- Humans
- Hyperparathyroidism, Primary
(blood, etiology, pathology)
- Male
- Middle Aged
- Organ Size
- Parathyroid Glands
(metabolism, pathology)
- Parathyroid Hormone
(blood, metabolism)
- Parathyroid Neoplasms
(blood, complications, pathology)
- Vitamin D
(analogs & derivatives, blood, pharmacokinetics)
- Vitamin D Deficiency
(blood, pathology)
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