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Urinary dolichol--a doubtful marker of alcoholism.

Abstract
The purpose of this study was to replicate the results of Pullarkat and Raguthu and Roine et al. who found elevated levels of urinary dolichol (long-chain 2,3-dihydropolyprenols) in chronic alcoholic patients. We investigated a sample of 21 alcohol-dependent inpatients voluntarily entering detoxification treatment. Urinary dolichol was only slightly increased as compared to 21 healthy controls. When dolichol was related to urinary creatinine no differences between alcoholic patients and controls could be found. Under conditions of confirmed abstinence the slightly elevated levels of dolichol returned to normal within 2 weeks. Compared with the sensitivity of gamma-glutamyltransferase which ranges from 72-85%, the value of urinary dolichol (sensitivity 9-19%) as a biochemical marker of alcoholism must be doubted.
AuthorsF Stetter, H J Gaertner, G Wiatr, K Mann, U Breyer-Pfaff
JournalAlcoholism, clinical and experimental research (Alcohol Clin Exp Res) Vol. 15 Issue 6 Pg. 938-41 (Dec 1991) ISSN: 0145-6008 [Print] England
PMID1686372 (Publication Type: Journal Article)
Chemical References
  • Dolichols
  • Ethanol
  • Creatinine
  • gamma-Glutamyltransferase
Topics
  • Adult
  • Alcoholism (diagnosis, enzymology, rehabilitation)
  • Creatinine (urine)
  • Dolichols (urine)
  • Ethanol (pharmacokinetics)
  • Female
  • Humans
  • Liver Function Tests
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • gamma-Glutamyltransferase (blood)

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