Abstract | PURPOSE: METHODS:
Paclitaxel-encapsulated PEO-modified PbAE (PEO-PbAE) nanoparticles were prepared by the solvent displacement method. PEO-modified poly(epsilon-caprolactone) ( PCL) (PEO-PCL) nanoparticles were used as a non pH-responsive control formulation. Efficacy studies were conducted in SKOV-3 tumor-bearing athymic (Nu/Nu) mice at an equivalent paclitaxel dose of 20 mg/kg with the control and nanoparticle formulations. Safety of the drug when administered in the control and nanoparticle formulation was determined from blood cell counts and changes in body weight of the animals. RESULTS: The formulated paclitaxel-containing PEO-PbAE and PEO-PCL nanoparticles had a particle size in the range of 100-200 nm and a surface charge of + 39.0 and - 30.8 mV, respectively. After intravenous administration of paclitaxel in these formulations, the tumor growth was inhibited significantly. Both of the formulated nanoparticles tested have shown improved therapeutic efficacy as compared to the paclitaxel aqueous solution. Additionally, significantly lower toxicity profile of paclitaxel was observed with PEO-modified nanoparticles as compared to the aqueous solution formulation CONCLUSION: PEO-modified PbAE nanoparticles are a unique pH-sensitive drug delivery system that elicits enhanced efficacy and safety profile in solid tumor therapy.
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Authors | Harikrishna Devalapally, Dinesh Shenoy, Steven Little, Robert Langer, Mansoor Amiji |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 59
Issue 4
Pg. 477-84
(Mar 2007)
ISSN: 0344-5704 [Print] Germany |
PMID | 16862429
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Polyesters
- polycaprolactone
- Polyethylene Glycols
- Paclitaxel
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Topics |
- Animals
- Cell Line, Tumor
- Chemistry, Pharmaceutical
- Drug Delivery Systems
- Female
- Humans
- Hydrogen-Ion Concentration
- Mice
- Nanoparticles
- Neoplasm Transplantation
- Ovarian Neoplasms
(drug therapy)
- Paclitaxel
(administration & dosage, adverse effects)
- Polyesters
(administration & dosage)
- Polyethylene Glycols
- Transplantation, Heterologous
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