Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infection.

Abstract

We confirmed findings from previous studies that cellulose sulfate gel can interfere with nucleic acid amplification tests used for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae. We therefore recommend that the effects of microbicide gels on diagnostic assays of sexually transmitted infections be established before starting up clinical studies.

• Authors: Tania Crucitti, Vicky Jespers, Lut Van Damme, Eddy Van Dyck, Anne Buvé
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 57 Issue 1 Pg. 97-9 (Jan 2007) ISSN: 0732-8893 [Print] United States
• PMID: 16860515 (Publication Type: Clinical Trial, Phase III, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gels
• Cellulose
• cellulose sulfate

Topics

• Cellulose (administration & dosage, analogs & derivatives, pharmacology)
• Chlamydia Infections (diagnosis, microbiology, prevention & control)
• Chlamydia trachomatis (genetics, isolation & purification)
• Female
• Gels
• Gonorrhea (diagnosis, microbiology, prevention & control)
• Humans
• Neisseria gonorrhoeae (genetics, isolation & purification)
• Nucleic Acid Amplification Techniques (standards)
• Specimen Handling (methods)
• Vagina (chemistry, microbiology)