Abstract | OBJECTIVES: MATERIAL AND METHOD: Twenty-five medication-free subjects (23 males and 2 females), aged 7-16 (mean = 10.6 +/- 2.0) years participated in an 8-week open-label guanfacine study. Subjects were recruited from a specialty clinic for children with tic disorders over a four-year period. Eligibility criteria included presence of ADHD (any type), a tic disorder (any type), and being medication free for two weeks. Outcome measures included the Hyperactivity Index of the Conners Parent Questionnaire, the teacher-rated ADHD Rating Scale, and the Yale Global Tic Severity Scale (YGTSS). RESULTS: All subjects met criteria for ADHD (combined type N = 22; predominantly inattentive type N = 3) and a tic disorder ( Tourette's Disorder N = 20; chronic motor tic disorder N = 5). At an average dose of 2.0 +/- 0.6 mg/ day, guanfacine was associated with mean improvement of 27% on the Hyperactivity Index (N = 25; t = 4.61; p < 0.001), 32% on the total score of the teacher-rated ADHD Scale (N = 19; t = 5.27; p < 0.001), and 39% on the total tic severity scale (N = 19; t = 4.17; p < 0.001). Mild and statistically insignificant decreases in blood pressure and pulse were observed in the sample as a whole. Five subjects had endpoint systolic blood pressure below 1 SD from their age and gender norms. CONCLUSION: Results of this open-label study add to the growing data base on the safety and efficacy of guanfacine in children with ADHD and tic disorders.
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Authors | Vitharon Boon-yasidhi, Young S Kim, Lawrence Scahill |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 88 Suppl 8
Pg. S156-62
(Nov 2005)
ISSN: 0125-2208 [Print] Thailand |
PMID | 16856436
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic alpha-Agonists
- Guanfacine
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Topics |
- Adolescent
- Adrenergic alpha-Agonists
(administration & dosage, therapeutic use)
- Attention Deficit Disorder with Hyperactivity
(drug therapy)
- Blood Pressure
- Child
- Female
- Guanfacine
(administration & dosage, therapeutic use)
- Humans
- Male
- Prospective Studies
- Pulse
- Tic Disorders
(drug therapy)
- Treatment Outcome
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