The acute effect of phenylpropanolamine and brompheniramine on blood pressure in controlled hypertension: a randomized double-blind crossover trial.

Abstract

STUDY OBJECTIVE:

To determine the acute effect of phenylpropanolamine, 75 mg, and brompheniramine, 12 mg, in combination (PPA/B) on blood pressure in patients with controlled hypertension, using ambulatory blood pressure monitoring (ABPM).

DESIGN:

Randomized double-blind crossover trial.

SETTING:

Outpatient clinic at one medical center.

PARTICIPANTS:

13 healthy volunteers aged 36 to 64 years, receiving medication for hypertension.

INTERVENTIONS:

Following 24-hour baseline ABPM, participants were randomized to receive either placebo or PPA/B every 12 hours for three doses, while ABPM continued. After a 24-hour washout period, all participants received the crossover regimen.

MEASUREMENTS AND MAIN RESULTS:

No clinically important or statistically significant difference was noted for mean systolic and diastolic blood pressures during the baseline (125/75), PPA/B (127/72), and placebo (126/73) phases of the study. Within the first four hours of treatment, the mean change in systolic blood pressure from baseline between PPA/B and placebo phases was 1.7 mm Hg (95% CI -5.3 to 8.7), and mean change in diastolic blood pressure was 0.9 mm Hg (95% CI -1.6 to 3.5), excluding a first-dose pressor effect.

CONCLUSION:

When used as recommended, PPA/B, a commonly used over-the-counter cold medication, has no significant acute effect on blood pressure in patients with controlled hypertension.

• Authors: A S Petrulis, T F Imperiale, T Speroff
• Journal: Journal of general internal medicine (J Gen Intern Med) 1991 Nov-Dec Vol. 6 Issue 6 Pg. 503-6 ISSN: 0884-8734 [Print] United States
• PMID: 1684991 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Delayed-Action Preparations
• Drug Combinations
• Histamine H1 Antagonists
• brompheniramine, pseudoephedrine drug combination
• Phenylephrine
• Phenylpropanolamine
• Pseudoephedrine
• Brompheniramine

Topics

• Blood Pressure (drug effects)
• Blood Pressure Monitors
• Brompheniramine (pharmacology)
• Delayed-Action Preparations
• Double-Blind Method
• Drug Combinations
• Female
• Histamine H1 Antagonists (pharmacology)
• Humans
• Hypertension (physiopathology)
• Male
• Middle Aged
• Phenylephrine (pharmacology)
• Phenylpropanolamine (pharmacology)
• Pseudoephedrine