Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis.

Abstract

OBJECTIVE:

To determine the association between glutathione S-transferase (GST) polymorphisms and the risk of differentiated thyroid carcinoma (DTC) and benign thyroid tumors.

DESIGN:

Case-control study.

SETTING:

Tertiary care cancer center.

PATIENTS:

Two hundred one patients with DTC, 103 patients with benign thyroid tumors, and 680 cancer-free control subjects.

MAIN OUTCOME MEASURES:

Results of a polymerase chain reaction-based assay for genotyping. A multivariate logistic regression analysis was performed with adjustment for age, sex, ethnicity, tobacco use, and alcohol use.

RESULTS:

The patients with DTC were younger, more likely to be female and nonwhite, and less likely to smoke or consume alcohol than the controls. Overall, 55.2% of the DTC cases and 52.6% of the controls were null for the gene for GST-mu1 (GSTM1) (P = .52), and 25.4% of the DTC subjects and 20.6% of the controls were null for the GST-theta1 gene (GSTT1) (P = .15). However, 15.9% of the DTC cases but only 9.4% of the controls were null for both genes (P = .009). In addition, the results of the adjusted multivariate regression analysis suggested that having both null genotypes was associated with an increased risk for DTC (odds ratio [OR], 2.1 [95% confidence interval, 1.3-3.5; P = .003]). This was particularly true for women (OR, 2.5), current smokers (OR, 3.6), and nonwhites (OR, 5.6). A similar analysis demonstrated a nonsignificant association between these genotypes and benign thyroid tumors (OR, 1.5 [95% confidence interval, 0.7-3.0; P=.30).

CONCLUSIONS:

Our results suggest that the simultaneous presence of the GSTM1- and GSTT1-null genotypes is a susceptibility factor for DTC. Such knowledge may ultimately help refine cancer prevention efforts; however, larger studies are needed to verify these findings.

• Authors: Tang Ho, Chong Zhao, Rong Zheng, Zhensheng Liu, Qingyi Wei, Erich M Sturgis
• Journal: Archives of otolaryngology--head & neck surgery (Arch Otolaryngol Head Neck Surg) Vol. 132 Issue 7 Pg. 756-61 (Jul 2006) ISSN: 0886-4470 [Print] United States
• PMID: 16847185 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Glutathione Transferase

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Case-Control Studies
• Chi-Square Distribution
• Cross-Sectional Studies
• Female
• Genotype
• Glutathione Transferase (genetics)
• Humans
• Logistic Models
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Risk Factors
• Thyroid Neoplasms (genetics)