Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas.

Abstract

Tyr-3-Octreotide is a synthetic derivative of somatostatin and a somatostatin-receptor analogue. The iodine-123-labelled compound localizes somatostatin-receptor-positive tumours. In this paper two patients are reported in whom somatostatin receptors were demonstrated in vitro. In a 60-year-old female with an islet cell carcinoma of the pancreas, multiple liver metastases and previously unrecognized bone metastases in the right acetabulum could be diagnosed as the reason for a persistent hypoglycaemia. In a 60-year-old male an islet cell carcinoma of the pancreas was localized with 123I-Tyr-3-octreotide. The somatostatin receptors were demonstrated in vitro and the tumour was successfully treated with somatostatin. These studies demonstrate that 123I-Tyr-3-octreotide offers the possibility of localizing somatostatin-receptor-positive tumours and their metastases. Moreover the method makes it possible to determine the receptor status of a tumour in vivo.

• Authors: W Becker, J Marienhagen, R Scheubel, A Saptogino, W H Bakker, W A Breeman, F Wolf
• Journal: European journal of nuclear medicine (Eur J Nucl Med) Vol. 18 Issue 11 Pg. 924-7 ( 1991) ISSN: 0340-6997 [Print] Germany
• PMID: 1684323 (Publication Type: Case Reports, Journal Article)

Chemical References

• Iodine Radioisotopes
• Receptors, Neurotransmitter
• Receptors, Somatostatin
• Somatostatin
• Octreotide

Topics

• Adenoma, Islet Cell (chemistry, diagnostic imaging, secondary)
• Bone Neoplasms (diagnostic imaging, secondary)
• Female
• Humans
• Iodine Radioisotopes
• Liver Neoplasms (diagnostic imaging, secondary)
• Male
• Middle Aged
• Octreotide
• Pancreatic Neoplasms (chemistry, diagnostic imaging)
• Receptors, Neurotransmitter (analysis)
• Receptors, Somatostatin
• Somatostatin (analysis)
• Tomography, Emission-Computed, Single-Photon