Infant acute lymphoblastic leukemia with t(11;16)(q23;p13.3) and lineage switch into acute monoblastic leukemia.

Abstract

Rearrangements of the mixed-lineage leukemia (MLL) gene have been associated with a poor prognosis in infant acute lymphoblastic leukemia (ALL). Previously, MLL translocations involving the CREP-binding protein (CREBBP) gene at chromosome band 16p13.3 have primarily been reported in treatment-related acute myeloid leukemia, after chemotherapy for other primary malignancies using topoisomerase II inhibitors. We report a case of de novo infant ALL with t(11;16)(q23;p13.3). After chemotherapy, this patient developed an acute monoblastic leukemia (M5b) with retention of the t(11;16)(q23;p13.3), indicating that this is a lineage switch of the original leukemic clone. To our knowledge, these findings have not been previously reported.

• Authors: Christopher Stasik, Siddhartha Ganguly, Mark T Cunningham, Stacey Hagemeister, Diane L Persons
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 168 Issue 2 Pg. 146-9 (Jul 15 2006) ISSN: 0165-4608 [Print] United States
• PMID: 16843104 (Publication Type: Case Reports, Journal Article)

Topics

• Bone Marrow Cells (pathology)
• Cell Lineage
• Chromosomes, Human, Pair 11 (genetics)
• Chromosomes, Human, Pair 16 (genetics)
• Humans
• In Situ Hybridization, Fluorescence
• Infant
• Karyotyping
• Leukemia, Monocytic, Acute (genetics, pathology)
• Male
• Metaphase
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics, pathology)
• Translocation, Genetic (genetics)