HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.

Abstract
Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the organelle and remodeling of the cristae. Here we provide evidence that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion. OPA1 does not interfere with activation of the mitochondrial "gatekeepers" BAX and BAK, but it controls the shape of mitochondrial cristae, keeping their junctions tight during apoptosis. Tightness of cristae junctions correlates with oligomerization of two forms of OPA1, a soluble, intermembrane space and an integral inner membrane one. The proapoptotic BCL-2 family member BID, which widens cristae junctions, also disrupts OPA1 oligomers. Thus, OPA1 has genetically and molecularly distinct functions in mitochondrial fusion and in cristae remodeling during apoptosis.
AuthorsChristian Frezza, Sara Cipolat, Olga Martins de Brito, Massimo Micaroni, Galina V Beznoussenko, Tomasz Rudka, Davide Bartoli, Roman S Polishuck, Nika N Danial, Bart De Strooper, Luca Scorrano
JournalCell (Cell) Vol. 126 Issue 1 Pg. 177-89 (Jul 14 2006) ISSN: 0092-8674 [Print] United States
PMID16839885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Proto-Oncogene Proteins c-bcl-2
  • bcl-2 Homologous Antagonist-Killer Protein
  • bcl-2-Associated X Protein
  • GTP Phosphohydrolases
  • Opa1 protein (GTPase), mouse
Topics
  • Animals
  • Apoptosis (genetics)
  • Cell Line
  • GTP Phosphohydrolases (genetics, metabolism)
  • Membrane Fusion (physiology)
  • Mice
  • Mice, Knockout
  • Mitochondria (genetics, metabolism, ultrastructure)
  • Mitochondrial Membranes (metabolism, ultrastructure)
  • Proto-Oncogene Proteins c-bcl-2 (metabolism)
  • Signal Transduction (physiology)
  • Tight Junctions (metabolism, ultrastructure)
  • bcl-2 Homologous Antagonist-Killer Protein (metabolism)
  • bcl-2-Associated X Protein (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: