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Apoptotic effect of ganciclovir on primary effusion lymphoma cells infected with Kaposi's sarcoma-associated herpesvirus.

Abstract
We evaluated the cytotoxic and apoptotic effects of two purine nucleoside analogues, acyclovir (ACV) and ganciclovir (GCV), on lymphoma cells stably harboring Kaposi's sarcoma-associated herpesvirus (KSHV). Colorimetric caspase assay, flow cytometry, and immunoblotting with antibodies against apoptosis-related molecules revealed that GCV has cytotoxic activity toward KSHV-infected primary effusion lymphoma cells, while ACV has weak or little activity. In addition to the GCV-induced cytotoxicity, apoptosis via caspase-7/8, cleavage of poly(ADP-ribose) polymerase, and accumulation of p53 and p21 were induced by GCV treatment. In contrast, neither ACV nor GCV have cytotoxicity- or apoptosis-inducing activities toward uninfected cells.
AuthorsMasahiro Fujimuro, Hisanori Inoue, Yasuhiro Teishikata, Yuriko Ishida, Hideyoshi Yokosawa
JournalNucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) Vol. 25 Issue 4-6 Pg. 635-45 ( 2006) ISSN: 1525-7770 [Print] United States
PMID16838851 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Caspase 3
  • Caspase 7
  • Ganciclovir
  • Acyclovir
Topics
  • Acyclovir (pharmacology)
  • Apoptosis (drug effects)
  • Caspase 3 (metabolism)
  • Caspase 7 (metabolism)
  • Ganciclovir (pharmacology, therapeutic use)
  • Herpesvirus 8, Human (physiology)
  • Humans
  • Lymphoma (drug therapy, pathology, virology)
  • Tumor Cells, Cultured

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