Abstract | AIM: MATERIALS AND METHODS: Female Sprague-Dawley albino rats were used in the study. Animals were divided into 5 groups: normal control; hypercalcemic rats bearing DMBA-induced mammary tumors; flare hypercalcemic animals bearing DMBA-induced mammary tumors (hypercalcemic rats, treated with tamoxifen at the dose of 10 mg/kg); flare hypercalcemic rat bearing DMBA-induced mammary tumors, treated with gallium nitrate at the dose of 2.5 mg/kg; control rats, treated with gallium nitrate at the dose of 2.5 mg/kg. Eligibility criteria - serum calcium levels were 11.0 mg% or above. Biochemical parameters were measured, using standard methods. Urinary excretion of calcium, creatinine ratio, urinary bone marker were also evaluated by using standard method. RESULTS: CONCLUSIONS:
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Authors | G Arumugam, P Shanthi, P Sachdanandam |
Journal | Experimental oncology
(Exp Oncol)
Vol. 28
Issue 2
Pg. 141-5
(Jun 2006)
ISSN: 1812-9269 [Print] Ukraine |
PMID | 16837906
(Publication Type: Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Tamoxifen
- Gallium
- Calcium
- gallium nitrate
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Antineoplastic Agents, Hormonal
(toxicity)
- Bone Neoplasms
(drug therapy, secondary)
- Calcium
(blood, urine)
- Female
- Gallium
(therapeutic use)
- Hypercalcemia
(chemically induced, drug therapy)
- Mammary Neoplasms, Animal
(complications, drug therapy, pathology)
- Rats
- Rats, Sprague-Dawley
- Tamoxifen
(toxicity)
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