Abstract |
Interferon-alpha (IFN-Alpha) + cisplatin (CDDP) + 5-FU therapy was given to 10 patients with gemcitabine (GEM)-refractory unresectable or recurrent pancreatic cancer. CDDP (35 mg/m(2)) was administered intravenously on the first day, IFN-Alpha (5x10(6)IU) subcutaneously on day 2,4 and 6 of each week, and 5-FU (175 mg/m(2)/day) continuously infused every day for 4 weeks. The 10 patients consisted of 8 men and 2 women with a mean age of 56.2 years. As the main site of progression, 5 patients had liver metastases, 1 had lung metastases, 2 had peritoneal dissemination, and 2 had local recurrence. The objective response rate was 30%, including 1 complete response. Grade 3 anorexia, neutropenia and thrombocytopenia occurred in 60%, 40% and 40%, respectively. IFN-Alpha + CDDP + 5-FU therapy is an effective treatment for GEM-refractory pancreatic cancer, but with moderate toxicity.
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Authors | Michio Ueda, Itaru Endo, Yoshiro Fujii, Yasuhiko Miura, Toru Kubota, Kuniya Tanaka, Yasushi Ichikawa, Shinji Togo, Hiroshi Shimada |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 33
Issue 7
Pg. 937-40
(Jul 2006)
ISSN: 0385-0684 [Print] Japan |
PMID | 16835483
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Interferon-alpha
- Deoxycytidine
- Cisplatin
- Fluorouracil
- Gemcitabine
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Topics |
- Aged
- Anorexia
(chemically induced)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Cisplatin
(administration & dosage)
- Deoxycytidine
(analogs & derivatives, pharmacology)
- Drug Administration Schedule
- Drug Resistance, Neoplasm
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Interferon-alpha
(administration & dosage)
- Male
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
(drug therapy)
- Neutropenia
(chemically induced)
- Pancreatic Neoplasms
(drug therapy, pathology)
- Thrombocytopenia
(chemically induced)
- Gemcitabine
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