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[Interferon-alpha+cisplatin+5-FU therapy for gemcitabine-refractory unresectable and recurrent pancreatic cancer].

Abstract
Interferon-alpha (IFN-Alpha) + cisplatin (CDDP) + 5-FU therapy was given to 10 patients with gemcitabine (GEM)-refractory unresectable or recurrent pancreatic cancer. CDDP (35 mg/m(2)) was administered intravenously on the first day, IFN-Alpha (5x10(6)IU) subcutaneously on day 2,4 and 6 of each week, and 5-FU (175 mg/m(2)/day) continuously infused every day for 4 weeks. The 10 patients consisted of 8 men and 2 women with a mean age of 56.2 years. As the main site of progression, 5 patients had liver metastases, 1 had lung metastases, 2 had peritoneal dissemination, and 2 had local recurrence. The objective response rate was 30%, including 1 complete response. Grade 3 anorexia, neutropenia and thrombocytopenia occurred in 60%, 40% and 40%, respectively. IFN-Alpha + CDDP + 5-FU therapy is an effective treatment for GEM-refractory pancreatic cancer, but with moderate toxicity.
AuthorsMichio Ueda, Itaru Endo, Yoshiro Fujii, Yasuhiko Miura, Toru Kubota, Kuniya Tanaka, Yasushi Ichikawa, Shinji Togo, Hiroshi Shimada
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 7 Pg. 937-40 (Jul 2006) ISSN: 0385-0684 [Print] Japan
PMID16835483 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Interferon-alpha
  • Deoxycytidine
  • Cisplatin
  • Fluorouracil
  • Gemcitabine
Topics
  • Aged
  • Anorexia (chemically induced)
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Cisplatin (administration & dosage)
  • Deoxycytidine (analogs & derivatives, pharmacology)
  • Drug Administration Schedule
  • Drug Resistance, Neoplasm
  • Female
  • Fluorouracil (administration & dosage)
  • Humans
  • Interferon-alpha (administration & dosage)
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local (drug therapy)
  • Neutropenia (chemically induced)
  • Pancreatic Neoplasms (drug therapy, pathology)
  • Thrombocytopenia (chemically induced)
  • Gemcitabine

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