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Disseminated granuloma annulare: efficacy of cyclosporine therapy.

Abstract
Granuloma annulare is an anatomo-clinical entity that is frequently encountered in everyday dermatological practice. We report our experience regarding 4 patients with disseminated granuloma annulare. Each patient was treated with a cycle of cyclosporine therapy for six weeks. A cycle of systemic cyclosporine therapy was started at a dose of 4 mg/kg/day for four weeks, subsequently reduced by 0.5 mg/kg/day every two weeks. The clinical picture more or less completely resolved within three weeks in all of the patients, and there were no relapses during the dose-tapering period or the following 12 months. Cyclosporine was optimally tolerated by all four patients, none of whom experienced any therapy-related side effects. Cyclosporine is a valid therapeutic option for the treatment of disseminated granuloma annulare, although we recommend its use in a protected hospital environment that facilitates patient monitoring.
AuthorsS Spadino, A Altomare, C Cainelli, C Franchi, E Frigerio, C Garutti, M Taglioni, G F Altomare
JournalInternational journal of immunopathology and pharmacology (Int J Immunopathol Pharmacol) 2006 Apr-Jun Vol. 19 Issue 2 Pg. 433-8 ISSN: 0394-6320 [Print] England
PMID16831309 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Cyclosporine
Topics
  • Cyclosporine (therapeutic use)
  • Female
  • Granuloma Annulare (drug therapy, pathology)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Middle Aged
  • Skin (pathology)

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