Abstract |
Granuloma annulare is an anatomo-clinical entity that is frequently encountered in everyday dermatological practice. We report our experience regarding 4 patients with disseminated granuloma annulare. Each patient was treated with a cycle of cyclosporine therapy for six weeks. A cycle of systemic cyclosporine therapy was started at a dose of 4 mg/kg/day for four weeks, subsequently reduced by 0.5 mg/kg/day every two weeks. The clinical picture more or less completely resolved within three weeks in all of the patients, and there were no relapses during the dose-tapering period or the following 12 months. Cyclosporine was optimally tolerated by all four patients, none of whom experienced any therapy-related side effects. Cyclosporine is a valid therapeutic option for the treatment of disseminated granuloma annulare, although we recommend its use in a protected hospital environment that facilitates patient monitoring.
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Authors | S Spadino, A Altomare, C Cainelli, C Franchi, E Frigerio, C Garutti, M Taglioni, G F Altomare |
Journal | International journal of immunopathology and pharmacology
(Int J Immunopathol Pharmacol)
2006 Apr-Jun
Vol. 19
Issue 2
Pg. 433-8
ISSN: 0394-6320 [Print] England |
PMID | 16831309
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Cyclosporine
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Topics |
- Cyclosporine
(therapeutic use)
- Female
- Granuloma Annulare
(drug therapy, pathology)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Middle Aged
- Skin
(pathology)
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