Impact of bilateral pallidal stimulation on DYT1-generalized dystonia in Japanese patients.

Abstract

Early-onset generalized dystonia attributable to a DYT1 gene mutation is a hyperkinetic movement disorder that responds poorly to pharmacotherapy. In this video brief, we show that continuous bilateral stimulation of the globus pallidus internus produced sustained and marked improvements in the motor symptoms and functional disabilities of Japanese patients with DYT1-generalized dystonia.

• Authors: Satoshi Goto, Kazumichi Yamada, Hideki Shimazu, Nagako Murase, Kazuhito Matsuzaki, Tetsuya Tamura, Shinji Nagahiro, Jun-ichi Kuratsu, Ryuji Kaji
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 21 Issue 10 Pg. 1785-7 (Oct 2006) ISSN: 0885-3185 [Print] United States
• PMID: 16830314 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Molecular Chaperones
• TOR1A protein, human

Topics

• Adolescent
• Adult
• Child
• Chromosome Deletion
• Deep Brain Stimulation (methods)
• Disability Evaluation
• Dominance, Cerebral (physiology)
• Dystonia (genetics, physiopathology, therapy)
• Electrodes, Implanted
• Follow-Up Studies
• Globus Pallidus (physiopathology)
• Humans
• Hyperkinesis (genetics, physiopathology, therapy)
• Japan
• Male
• Molecular Chaperones (genetics)
• Trinucleotide Repeats