Abstract | BACKGROUND: METHODS: We prospectively enrolled 810 consecutive candidates for CABG alone in a specific database, including all pre- and perioperative data (history, clinical, therapeutic, cardiac catheterization, surgical and intensive care data). Univariate tests and then multiple logistic regression analysis were used to determine independent predictive factors. RESULTS: During the first postoperative month, stroke occurred in 11 cases and transient ischemic attack (TIA) in 4 additive cases (cumulative rate: 1.85%). After the multivariate analysis, the following factors remained significant (p<0.05) in the predictive model, with corresponding odds ratios between brackets: redo cardiac surgery (7.45), unstable cardiac status (4.74), past history of cerebrovascular disease (4.14), past history of peripheral arterial disease (3.55), whereas the presence of preoperative statins was protective (0.24, 95% IC: 0.07-0.78). The addition of perioperative data (aortic calcification, postoperative arrhythmia, on/off-pump surgery) did not change the final predictive model. CONCLUSION: To our knowledge, this is the first real-world observational report highlighting the interest of statins for the prevention of stroke in the very special situation of CABG. Even though according to randomized trials coronary patients have a benefit from these drugs, a special level of interest should be directed towards those presenting the above-mentioned risk factors.
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Authors | Victor Aboyans, Louis Labrousse, Philippe Lacroix, Jérôme Guilloux, Seifeddine Sekkal, Alexandre Le Guyader, Elisabeth Cornu, Marc Laskar |
Journal | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
(Eur J Cardiothorac Surg)
Vol. 30
Issue 2
Pg. 300-4
(Aug 2006)
ISSN: 1010-7940 [Print] Germany |
PMID | 16829106
(Publication Type: Journal Article)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Aged
- Cardiopulmonary Bypass
- Cerebrovascular Disorders
(complications)
- Coronary Artery Bypass
(adverse effects)
- Epidemiologic Methods
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Male
- Middle Aged
- Peripheral Vascular Diseases
(complications)
- Reoperation
(adverse effects)
- Stroke
(etiology, prevention & control)
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