Changes of tumor necrosis factor, surfactant protein A, and phospholipids in bronchoalveolar lavage fluid in the development and progression of coal workers' pneumoconiosis.
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| Abstract | OBJECTIVE: To evaluate the alterations of biomarkers in the development and progression of coal workers' pneumoconiosis (CWP). METHODS: The type and number of cells, and the levels of tumor necrosis factor-alpha (TNF-alpha), pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1. RESULTS: Compared to active coal miners without CWP (8.23 microg/mL), TNF-alpha concentration was gradually decreased when dust exposure was stopped (5.90 microg/mL). Elevated surfactant protein A (SP-A) level and phosphatidylglycerol (PG) to phosphatidylinositol (PI) ratio were found in miners actively exposed to coal dust (6528 ng/mL for SP-A and 10. for PG/PI), and both parameters decreased when CWP progressed from CWP (0/1) (3419 microg/mL for SP-A and 5.9 for PG/PI) to CWP (1/1) (1654 microg/mL for SP-A and 5.5 for PG/PI). CONCLUSION:
Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers' pneumoconiosis.
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| Authors | Jing-Cai Xing, Wei-Hong Chen, Wen-Hui Han, Mei-Feng Guo, Steffeni Rehn, Joachim Bruch |
| Journal | Biomedical and environmental sciences : BES (Biomed Environ Sci) Vol. 19 Issue 2 Pg. 124-9 (Apr 2006) ISSN: 0895-3988 [Print] China |
| PMID | 16827183 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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