Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Patients with Hymenoptera venom allergy who suffer from mastocytosis develop life-threatening sting reactions more often than those who do not. When patients with Hymenoptera venom allergy were systematically examined for mastocytosis, it was found to be represented to an abnormally high extent. Most patients with mastocytosis tolerate venom immunotherapy with no or only minor systemic symptoms. Venom immunotherapy was found to be marginally less effective in patients with mastocytosis than in those without evidence of mast cell disease (defined as absent cutaneous mastocytosis combined with a serum tryptase concentration of <11.4 microg/l). Several deaths from sting reactions were reported in patients with mastocytosis after venom immunotherapy was stopped. These patients should have venom immunotherapy for the rest of their lives. SUMMARY:
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Authors | Franziska Ruëff, Marianne Placzek, Bernhard Przybilla |
Journal | Current opinion in allergy and clinical immunology
(Curr Opin Allergy Clin Immunol)
Vol. 6
Issue 4
Pg. 284-8
(Aug 2006)
ISSN: 1528-4050 [Print] United States |
PMID | 16825870
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Animals
- Arthropod Venoms
(immunology, poisoning)
- Humans
- Hymenoptera
(immunology)
- Hypersensitivity
(etiology, immunology)
- Mastocytosis
(immunology)
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