Abstract | BACKGROUND:
Biological markers for chronic alcohol consumption like MCV or gammaGT or carbohydrate deficient transferrin (CDT) are useful, but far from being perfect. In patients with liver disease a reliable marker for chronic alcohol consumption as the underlying etiology is highly needed. Recently, a new ELISA based version of the carbohydrate-deficient-transferrin (CDT-TRISIALO (-)) assay has been developed, which measures asialo-, monosialo- and disialo transferrin, but excludes trisialo- transferrin; that modification suggests higher sensitivity and specificity in detecting recent alcohol consumption in patients. AIMS: The study goal was to evaluate the sensitivity, specificity, positive and negative predicitive value of this new carbohydrate-deficient-transferrin assay (CDT-TRISIALO (-)) in a group of patients with liver disease and to compare the results with that of the established CDT assay (CDT-TRISIALO (+)). PATIENTS AND METHODS: RESULTS: In our population of liver disease patients the CDT-TRISIALO (-) assay had a sensitivity of 72.7 % and specificity of 58.1 % for recent alcohol consumption at the published cutoff level of 2.6 %. The positive predictive value was 34.0 % and the negative predictive value was 87.8 %. Sensitivity and specificity of the CDT-TRISIALO (+) assay at the recommended cutoff level of 4.7 % were similar, 77.3 % and 49.3 %, respectively. The positive and negative predictive values were 30.9 % and 88.1 %. CDTTRISIALO (+) and CDT-TRISIALO (-) levels increased significantly with higher Child-Pugh stages. CONCLUSION: The newly developed carbohydrate deficient transferrin test (CDT-TRISIALO (-)) is of no advantage as compared to the established assay (CDT-TRISIALO (+)) when used in a patient population with liver disease. In that population, normal CDT-TRISIALO (-) helps to exclude recent alcohol consumption; this results from the high negative predictive value of a normal CDT-TRISIALO (-).
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Authors | Maximilian Schöniger-Hekele, Katrin Ramskogler, Doris Hartl, Otto M Lesch, Christian Müller |
Journal | Wiener medizinische Wochenschrift (1946)
(Wien Med Wochenschr)
Vol. 156
Issue 7-8
Pg. 216-22
(Apr 2006)
ISSN: 0043-5341 [Print] Austria |
PMID | 16823539
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Protein Isoforms
- Sialoglycoproteins
- Transferrin
- carbohydrate-deficient transferrin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Chronic Disease
- Enzyme-Linked Immunosorbent Assay
(methods)
- Female
- Hemochromatosis
(blood, diagnosis)
- Hepatitis B, Chronic
(blood, diagnosis)
- Hepatitis C, Chronic
(blood, diagnosis)
- Humans
- Liver Diseases
(blood, diagnosis)
- Liver Diseases, Alcoholic
(blood, diagnosis)
- Male
- Middle Aged
- Protein Isoforms
(blood)
- Sensitivity and Specificity
- Sialoglycoproteins
(blood)
- Transferrin
(analogs & derivatives, metabolism)
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