Abstract | OBJECTIVES:
Malignant pleural effusion, a common complication seen in advanced lung cancer patients, is often treated with intrapleural administration of chemical agents. In Japan, OK-432, a biological response modifiers, which activates the cytotoxic activity of lymphocytes and boosts antitumor immunity, is among the most frequently used chemical agents. The purpose of this study was to determine, in a case-control study, whether or not the rate of lymphocytes in malignant pleural effusion (lymphocyte rate) influences the therapeutic efficacy of intrapleural OK-432. PATIENTS AND METHODS: RESULTS: Response rate in patients who had a high lymphocyte rate (the High lymphocyte rate group) was significantly higher than in patients who had a low lymphocyte rate (the Low lymphocyte rate group). Lymphocyte rate did not correlate with duration of chest drainage after treatment with intrapleural OK-432, time to progression of malignant pleural effusion, or survival time. CONCLUSIONS:
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Authors | Tetsuo Shimizu, Noriaki Takahashi, Masahiro Terakado, Hiroshi Akusawa, Ichiro Tsujino, Takashi Horie |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 45
Issue 11
Pg. 715-20
( 2006)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 16819251
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Picibanil
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Topics |
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(therapeutic use)
- Case-Control Studies
- Disease Progression
- Drainage
- Female
- Humans
- Lung Neoplasms
(complications, drug therapy, physiopathology)
- Lymphocytes, Tumor-Infiltrating
(physiology)
- Male
- Middle Aged
- Picibanil
(therapeutic use)
- Pleural Cavity
(pathology)
- Pleural Effusion, Malignant
(drug therapy, etiology, physiopathology)
- Survival Rate
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