Maintenance oral sulfasalazine prolongs remission in ulcerative proctitis and proctosigmoiditis.

Abstract

We have retrospectively compared the effectiveness of five different regimens for inducing and maintaining clinical remission in 206 patients with idiopathic proctitis (n = 115) and proctosigmoiditis (n = 91). The five therapeutic regimens were: corticosteroid enemas, 5-aminosalicylic acid (5-ASA) enemas, oral 5-ASA (sulfasalazine or mesalamine), corticosteroid enemas plus oral 5-ASA, or 5-ASA enemas plus oral 5-ASA. Clinical remission was achieved within 28 days of therapy in 47%, and eventually in 94% of these patients. No significant differences in efficacy were found among the five regimens. Most patients ultimately experienced a recurrence of symptoms, but the duration of remission was significantly longer with maintenance oral sulfasalazine or mesalamine (17.2 months) than with no therapy (11.8 months), P less than 0.01. We conclude that several regimens are equally effective in inducing remission of proctitis and proctosigmoiditis, although prolonged therapy may be needed to accomplish this goal. Maintenance oral 5-ASA significantly prolongs symptomatic remission in proctitis and proctosigmoiditis.

• Authors: D LaRosa, P H Rubin, C Bodian, D H Present
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 86 Issue 10 Pg. 1456-60 (Oct 1991) ISSN: 0002-9270 [Print] United States
• PMID: 1681725 (Publication Type: Journal Article)

Chemical References

• Sulfasalazine

Topics

• Adolescent
• Adult
• Aged
• Child
• Colitis, Ulcerative (drug therapy, prevention & control)
• Female
• Humans
• Male
• Middle Aged
• Proctitis (drug therapy)
• Recurrence
• Remission Induction
• Retrospective Studies
• Sulfasalazine (administration & dosage)
• Time Factors