Follicular adenomatoid odontogenic tumor: immunohistochemical study.

Abstract

Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic lesion that affects young patients, with female predominance, mainly in second decade, showing a radiolucent unilocular image associated with an unerupted tooth, usually a canine. In spite of previous and confusing denominations, such as adenoameloblastoma or adenomatoid ameloblastic tumor, AOT is a benign tumor with a very low rate of recurrence, that show a peculiar morphological picture (basaloid appearance with glandular-like structures, calcifying areas, and amiloid-like material) that allow its histopathological recognition. We present a clinicopathological analysis of a case of follicular AOT affecting the mandible in a 9 years-old female patient associated with unerupted lower left canine. Immunohistochemical study showed some data previously unrecognised. All cellular types that composed AOT showed nuclear positivity for p63 indicating a basal characterization in the different cellular components. According to its benign character and low potential for recurrence, AOT revealed a scant proliferative activity (2-3% nuclei showed Ki-67 positivity) limited to some epithelial nodules (AE1-3 +) of fusiform appearance. Absence of reactivity for hormonal receptors (RE and RPg) excluded a possible hormonodependence in AOT that could explain the observed female predominance.

• Authors: Francisco José Vera Sempere, María Jose Artes Martínez, Beatriz Vera Sirera, Jaime Bonet Marco
• Journal: Medicina oral, patologia oral y cirugia bucal (Med Oral Patol Oral Cir Bucal) Vol. 11 Issue 4 Pg. E305-8 (Jul 01 2006) ISSN: 1698-6946 [Electronic] Spain
• PMID: 16816813 (Publication Type: Case Reports, Journal Article)

Topics

• Adenoma (pathology)
• Child
• Female
• Humans
• Immunohistochemistry
• Mandibular Neoplasms (pathology)
• Odontogenic Tumors (pathology)