[Vitamin D and phosphate metabolism; relationship with aging-regulating gene].

Abstract

It has been known that phosphate homeostasis is mainly regulated by parathyroid hormone and vitamin D. Fibroblast growth factor 23 (FGF23) has been identified as a novel factor that regulates vitamin D and phosphate metabolism. Genetic defect of FGF23 in mice revealed not only abnormal vitamin D and phosphate metabolism, but also premature aging-like phenotype that is quite similar to Klotho mice. Regulation of vitamin D and phosphate metabolism is closely related to aging processes as well as bone and mineral metabolism.

• Authors: Yutaka Taketani, Hironori Yamamoto, Eiji Takeda, Ken-ichi Miyamoto
• Journal: Clinical calcium (Clin Calcium) Vol. 16 Issue 7 Pg. 1137-42 (Jul 2006) ISSN: 0917-5857 [Print] Japan
• PMID: 16816473 (Publication Type: Journal Article, Review)

Chemical References

• FGF23 protein, human
• Fgf23 protein, mouse
• Forkhead Transcription Factors
• Phosphates
• Phosphorus, Dietary
• Vitamin D
• Fibroblast Growth Factors
• Insulin-Like Growth Factor I
• Fibroblast Growth Factor-23
• Glucuronidase
• Klotho Proteins

Topics

• Aging (genetics)
• Aging, Premature (genetics)
• Animals
• Bone and Bones (metabolism)
• Fibroblast Growth Factor-23
• Fibroblast Growth Factors (physiology)
• Forkhead Transcription Factors
• Glucuronidase (genetics)
• Humans
• Insulin-Like Growth Factor I (physiology)
• Klotho Proteins
• Mice
• Phosphates (metabolism)
• Phosphorus, Dietary (administration & dosage)
• Signal Transduction (genetics, physiology)
• Vitamin D (adverse effects, metabolism, physiology)