Exploring QSAR on 3-aminopyrazoles as antitumor agents for their inhibitory activity of CDK2/cyclin A.

Abstract

Chemical inhibitors of cyclin-dependent kinases have great therapeutic potential against various proliferative and neurodegenerative disorders. The pharmacophoric requirement of 3-aminopyrazole, inhibitors of CDK2/cyclin A as antitumor agents was explored. QSAR study was performed using ETSA index, RTSA index, indicator parameters and atomic charges to consider quantitatively the effect of the structural variation on the antitumor activity of 3-aminopyrazole. Result showed that atom number 5 is important for the activity. It plays some electronic roles in the interaction of these compounds with enzymes as well as assumed to be involved through the dispersive/van der Waals interactions with enzyme. Presence of meta substitutions on the phenyl ring indicate the detrimental effects towards the activity. The presence of substituted biphenyl/2-thenyl phenyl at R1 are favorable towards the activity. QSAR study also indicates that with increasing the electronegativity of oxygen at position 8, the activity increases.

• Authors: Soma Samanta, Bikash Debnath, Anindya Basu, Shovanlal Gayen, Kolluru Srikanth, Tarun Jha
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 41 Issue 10 Pg. 1190-5 (Oct 2006) ISSN: 0223-5234 [Print] France
• PMID: 16806589 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3-aminopyrazole
• Antineoplastic Agents
• Cyclin A
• Pyrazoles
• Cyclin-Dependent Kinase 2

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Cyclin A (antagonists & inhibitors)
• Cyclin-Dependent Kinase 2 (antagonists & inhibitors)
• Drug Design
• Pyrazoles (chemistry, pharmacology)
• Quantitative Structure-Activity Relationship