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Calcium acetate used as phosphate binding treatment in uremic hyperphosphatemia.

Abstract
Due to toxic side effects of aluminum-containing agents for treatment of uremic hypophosphatemia, much interest has been focused upon aluminum-free phosphate binder alternatives. From results of experimental studies with calcium acetate, this salt has been suggested as a possible effective and safe phosphate binder. In the present study, calcium acetate was used during a mean of 11 months for serum phosphate control in 30 uremic patients previously treated with aluminum and/or calcium carbonate. Satisfactory control of serum phosphate was achieved during the study (mean phosphate concentration +/- SE: 2.15 +/- 0.12 mmol/l compared to prestudy 2.23 +/- 0.19 mmol/l). Mean serum concentrations of calcium, alkaline phosphatase and parathyroid hormone did not change significantly during the study. Serum aluminum decreased significantly (p less than 0.01). Moderate hypercalcemia was observed in 6 patients. Calcium acetate treatment was withdrawn in 2 patients due to gastrointestinal discomfort. It is concluded that calcium acetate seems to be an effective phosphate binder alternative with relatively few side effects.
AuthorsB Wikström, B G Danielson, B Fellström
JournalAdvances in peritoneal dialysis. Conference on Peritoneal Dialysis (Adv Perit Dial) Vol. 7 Pg. 221-4 ( 1991) ISSN: 1197-8554 [Print] Canada
PMID1680430 (Publication Type: Journal Article)
Chemical References
  • Acetates
  • Parathyroid Hormone
  • Phosphates
  • Aluminum Hydroxide
  • Aluminum
  • Alkaline Phosphatase
  • Calcium Carbonate
  • Acetic Acid
Topics
  • Acetates (therapeutic use)
  • Acetic Acid
  • Adolescent
  • Adult
  • Aged
  • Alkaline Phosphatase (blood)
  • Aluminum (blood)
  • Aluminum Hydroxide (therapeutic use)
  • Calcium Carbonate (therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Hormone (blood)
  • Phosphates (blood)
  • Uremia (blood)

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