Abstract | OBJECTIVE: DATA SOURCES: The MEDLINE, EMBASE, CINAHL (Cumulative Index to Nursing and Allied Health), and Cochrane databases; review articles; and references of included trials. STUDY SELECTION: Published (1966-2005) randomized controlled trials with nasal and eye symptoms and quality-of-life scores as primary outcomes. RESULTS: Seventeen studies including 6,231 adults with seasonal allergic rhinitis were selected. Oral leukotriene antagonists significantly reduced daytime nasal symptoms (standardized mean difference [SMD], -0.24; 95% confidence interval [CI], -0.33 to -0.16), nighttime nasal symptoms (SMD, -0.23; 95% CI, -0.30 to -0.16), and eye symptoms and significantly improved quality of life compared with placebo. There were no significant differences between oral leukotriene antagonists and oral histamine H1 antagonists on nasal and eye symptoms and quality-of-life overall score. We also found that leukotriene receptor antagonists were inferior to intranasal corticosteroids for decreasing daytime (SMD, 0.41; 95% CI, 0.27 to 0.56) and nighttime nasal symptoms. The combination of leukotriene receptor antagonists plus histamine H1 antagonists produced greater relief of eye symptoms compared with histamine H1 antagonists alone. Finally, intranasal corticosteroids significantly reduced nasal congestion compared with leukotriene receptor antagonists plus histamine H1 antagonists. CONCLUSIONS:
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Authors | Gustavo J Rodrigo, Anahi Yañez |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 96
Issue 6
Pg. 779-86
(Jun 2006)
ISSN: 1081-1206 [Print] United States |
PMID | 16802764
(Publication Type: Comparative Study, Journal Article, Review, Systematic Review)
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Chemical References |
- Adrenal Cortex Hormones
- Histamine H1 Antagonists
- Leukotriene Antagonists
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Topics |
- Administration, Intranasal
- Administration, Oral
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Histamine H1 Antagonists
(administration & dosage, therapeutic use)
- Humans
- Leukotriene Antagonists
(administration & dosage, therapeutic use)
- Meta-Analysis as Topic
- Randomized Controlled Trials as Topic
- Rhinitis, Allergic, Seasonal
(drug therapy)
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