Radioguided occult lesion localisation in combination with detection of the sentinel lymph node in non-palpable breast cancer tumours.

Abstract

PURPOSE OF THE INVESTIGATION:

The aim of study was to determine the efficacy of radioguided occult lesion localisation (ROLL) for non-palpable invasive breast cancer combined with sentinel lymph node biopsy (SLNB) and to compare the amount of tissue excised by radioguided navigation versus the hook-wire technique.

METHODS:

We injected 45 MBq of radiolabelled technetium intratumourally and 15 MBq subdermally 18 hours before surgery in 21 women with bioptically verified non-palpable breast cancer. We identified by gamma probe non-palpable tumours, which were excised, followed by identification and excision of the sentinel lymph node. We compared our results with a group of 12 women with non-palpable lesions marked by hook-wire localisation.

RESULTS:

ROLL combined with SLNB was successful in 100%; volume of excised tissue was smaller in the hook-wire group but expressed higher variability in volume than in the ROLL group although the difference was not statistically significant.

CONCLUSION:

The method of ROLL combined with SLNB is technically possible and safe, resulting in minimisation of the surgical intervention and a decrease in postoperative morbidity. ROLL was more precise than the hook-wire procedure even though the amount of tissue excised was the same in both groups.

• Authors: P Strnad, L Rob, M G Halaska, J Chod, A Zuntova, Z Moravcova
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 27 Issue 3 Pg. 236-8 ( 2006) ISSN: 0392-2936 [Print] Singapore
• PMID: 16800248 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Radiopharmaceuticals
• Technetium Compounds

Topics

• Adult
• Aged
• Breast Neoplasms (diagnostic imaging, pathology, surgery)
• Female
• Humans
• Middle Aged
• Radionuclide Imaging
• Radiopharmaceuticals
• Sentinel Lymph Node Biopsy
• Technetium Compounds