Plasma exchange in severe hypertriglyceridemia a clinical study.

Abstract

BACKGROUND:

Hypercholesterolemia and hypertriglyceridemia are independent risk factors for atherosclerotic heart diseases. Moreover acute pancreatitis may occur in patients with severe hypertriglyceridemia.

AIM OF THE STUDY:

To evaluate the effectiveness of plasma exchange (PE) in patients with severe hypertriglyceridemia.

METHODS:

Seven patients with severe hypertriglyceridemia (a triglyceride level of more than 1000mg/dl) were treated with PE. After PE, lipid and hematological parameters and side effects were evaluated.

RESULTS:

Triglyceride levels decreased below 1000mg/dl in all patients. The levels of triglyceride and very low-density lipoprotein cholesterol (p<0.05 for both), and total cholesterol (p<0.005) decreased significantly. PE was well-tolerated. Liver and renal functions, hematological parameters, except for an increase in white blood cell counts, did not change significantly.

CONCLUSION:

PE may be used safely and effectively in severe hyperlipidemic patients at risk of acute coronary events and acute pancreatitis. Further extended studies may provide more detailed information.

• Authors: Gurhan Kadikoylu, Irfan Yavasoglu, Zahit Bolaman
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 34 Issue 3 Pg. 253-7 (Jun 2006) ISSN: 1473-0502 [Print] England
• PMID: 16798091 (Publication Type: Clinical Trial, Journal Article)

Topics

• Humans
• Hypertriglyceridemia (therapy)
• Plasma Exchange (adverse effects)