The purpose of this study was to evaluate both the intraocular pressure (IOP)-decreasing and
neuroprotective effects of
Rescula (0.12%
unoprostone isopropyl) as an alternative
therapy to betablockers with a long-term drift effect in patients with
glaucoma. Twenty-eight patients with unilateral or bilateral
glaucoma were treated with
Rescula instead of the original beta-blocker
therapy. IOP was measured using a Goldmann applanation tonometer, and visual field defects were evaluated quantitatively by Humphrey automatic perimetry central 30-2 threshold test. The mean follow-up time was at least 1 year.
Rescula achieved a significant (p = 0.00001) and long-lasting reduction in IOP (from 20.78 +/- 2.71 to 17.14 +/- 2.70 mmHg) in patients with
open-angle glaucoma after 12 months of follow-up. It also demonstrated a significant (p = 0.02) IOP-reducing effect (from 20.67 +/- 3.60 to 16.36 +/- 3.67 mmHg) in patients with
angle-closure glaucoma 12 months later. The mean deviation of visual field defects changed from -13.27 dB baseline to -10.64 dB at 12 months as evaluated by Humphrey field analyzer II central 30-2 threshold test after
Rescula; however, there was no statistical difference (p = 0.098). Our results showed that
Rescula has a significant IOP-reducing effect as an alternative
therapy to beta-blockers with long-term drift effect in patients with open-angle and
angle-closure glaucoma. However, a
neuroprotective effect to prevent further progression of the visual field defect in patients with
glaucoma was not demonstrated in this study.