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Rescula as an alternative therapy for beta-blockers with long-term drift effect in glaucoma patients.

Abstract
The purpose of this study was to evaluate both the intraocular pressure (IOP)-decreasing and neuroprotective effects of Rescula (0.12% unoprostone isopropyl) as an alternative therapy to betablockers with a long-term drift effect in patients with glaucoma. Twenty-eight patients with unilateral or bilateral glaucoma were treated with Rescula instead of the original beta-blocker therapy. IOP was measured using a Goldmann applanation tonometer, and visual field defects were evaluated quantitatively by Humphrey automatic perimetry central 30-2 threshold test. The mean follow-up time was at least 1 year. Rescula achieved a significant (p = 0.00001) and long-lasting reduction in IOP (from 20.78 +/- 2.71 to 17.14 +/- 2.70 mmHg) in patients with open-angle glaucoma after 12 months of follow-up. It also demonstrated a significant (p = 0.02) IOP-reducing effect (from 20.67 +/- 3.60 to 16.36 +/- 3.67 mmHg) in patients with angle-closure glaucoma 12 months later. The mean deviation of visual field defects changed from -13.27 dB baseline to -10.64 dB at 12 months as evaluated by Humphrey field analyzer II central 30-2 threshold test after Rescula; however, there was no statistical difference (p = 0.098). Our results showed that Rescula has a significant IOP-reducing effect as an alternative therapy to beta-blockers with long-term drift effect in patients with open-angle and angle-closure glaucoma. However, a neuroprotective effect to prevent further progression of the visual field defect in patients with glaucoma was not demonstrated in this study.
AuthorsChang-Lin Chen, Hang-Yi Tseng, Kwou-Yeung Wu
JournalThe Kaohsiung journal of medical sciences (Kaohsiung J Med Sci) Vol. 22 Issue 6 Pg. 266-70 (Jun 2006) ISSN: 1607-551X [Print] China (Republic : 1949- )
PMID16793563 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Antihypertensive Agents
  • Neuroprotective Agents
  • isopropyl unoprostone
  • Dinoprost
Topics
  • Adrenergic beta-Antagonists (therapeutic use)
  • Adult
  • Aged
  • Antihypertensive Agents (therapeutic use)
  • Dinoprost (analogs & derivatives, pharmacology, therapeutic use)
  • Female
  • Glaucoma (drug therapy)
  • Humans
  • Intraocular Pressure (drug effects)
  • Male
  • Middle Aged
  • Neuroprotective Agents (pharmacology)
  • Prospective Studies
  • Visual Fields (drug effects)

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