Abstract | BACKGROUND: Localized chronic plaque psoriasis, resistant to local therapy, may be very hard to treat. The treatment of these lesions with a pulsed dye laser (PDL) has been described before, but a comparative study between the PDL and a potent topical treatment has never been performed. OBJECTIVES: METHODS: Eight patients with psoriasis were treated with both PDL (585 nm) and calcipotriol/ betamethasone dipropionate in an open, intrapatient, left-right comparison. A plaque severity score (sum score) and photographs were used to document the course of therapy. Patients reported pain on a visual analogue scale. RESULTS: Both treatments were well tolerated, although one patient left the study due to post-PDL treatment pain. A significant difference in the sum score 12 weeks after treatment was seen in favour of the PDL (62% vs. 19% reduction; P<0.05). Scores for erythema declined significantly at week 12 in both the PDL and the calcipotriol/ betamethasone dipropionate group (P<0.001). Induration and desquamation scores were significantly reduced at week 12 in the PDL group, without a statistically significant reduction in calcipotriol/ betamethasone-treated lesions. The pain scores declined with progressive PDL treatments, although not statistically significantly. CONCLUSIONS: PDL treatment might be considered for the treatment of localized, recalcitrant plaque psoriasis, when other topical therapies have failed.
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Authors | A Erceg, H J Bovenschen, P C M van de Kerkhof, M M B Seyger |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 155
Issue 1
Pg. 110-4
(Jul 2006)
ISSN: 0007-0963 [Print] England |
PMID | 16792761
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Dermatologic Agents
- Drug Combinations
- calcipotriene
- Betamethasone
- Calcitriol
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Topics |
- Adult
- Analysis of Variance
- Anti-Inflammatory Agents
(therapeutic use)
- Betamethasone
(therapeutic use)
- Calcitriol
(analogs & derivatives, therapeutic use)
- Dermatologic Agents
(therapeutic use)
- Drug Combinations
- Female
- Follow-Up Studies
- Humans
- Laser Therapy
- Male
- Middle Aged
- Psoriasis
(drug therapy, therapy)
- Treatment Outcome
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