Abstract | BACKGROUND: OBJECTIVE: METHODS: In this single center, retrospective, 2:1 matched, case-control study, the odds of SIP were assessed using univariate and multivariate logistic regression analysis in < or =14-day old VLBW infants. RESULTS: Sixteen VLBW infants with SIP were matched to 32 controls by birth weight. After adjusting for clinically relevant variables, patients who received > or =3 doses of indomethacin for ductal closure or intraventricular hemorrhage prophylaxis and > or =3 doses of low-dose dexamethasone (0.3 mg/kg cumulative dose over 3 days) for refractory hypotension during the first postnatal week, were 9.6 times more likely to develop SIP [95% CI 1.22, 75.71]. CONCLUSIONS:
|
Authors | L Paquette, P Friedlich, R Ramanathan, I Seri |
Journal | Journal of perinatology : official journal of the California Perinatal Association
(J Perinatol)
Vol. 26
Issue 8
Pg. 486-92
(Aug 2006)
ISSN: 0743-8346 [Print] United States |
PMID | 16791261
(Publication Type: Journal Article)
|
Chemical References |
- Dexamethasone
- Indomethacin
|
Topics |
- Case-Control Studies
- Dexamethasone
(administration & dosage, adverse effects)
- Ductus Arteriosus, Patent
(drug therapy)
- Female
- Humans
- Hypotension
(drug therapy)
- Indomethacin
(administration & dosage, adverse effects)
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
(chemically induced, drug therapy)
- Infant, Very Low Birth Weight
- Intestinal Perforation
(chemically induced)
- Male
- Risk Factors
|