HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Use of a new inotropic agent, enoximone, in heart surgery].

Abstract
We report our experience with the use of enoximone in 5 patients with severely depressed preoperative myocardial function who underwent cardiac surgery. In patients 1 and 2, enoximone was administered as the inotropic of choice before cardiopulmonary bypass (CPB) and a substantial improvement of cardiac index was achieved; in these patients, enoximone administration after CPB permitted to overcome low cardiac output which persisted after high dose dobutamine in patient 1, and in patient 2 right ventricular contractility improved. In patient 3 the use of enoximone permitted the discontinuation of CPB, which had not been previously possible with the association of dopamine and dobutamine. In this patient, adrenaline perfusion improved the low cardiac output syndrome but resulted in poorly tolerated side effects. However, in patient 4 the administration of enoximone during pre-CPB did not improve in a reduction in filling pressures without an increase in the cardiac index because the patient was hypovolemic. In patient 5, the administration of enoximone permitted to interrupt the infusion of dobutamine and to reduce the dose of sodium nitroprusside, which had resulted in significant tachycardia, with increased myocardial contractility and a reduction of vascular peripheral and pulmonary resistances. We conclude that enoximone, single or in association with other inotropics, should be considered a drug of choice in patients undergoing cardiac surgery who develop a low cardiac output syndrome.
AuthorsC Gomar, G Fita, J L Pomar, R Valero, J Mulet, M A Nalda
JournalRevista espanola de anestesiologia y reanimacion (Rev Esp Anestesiol Reanim) 1991 Mar-Apr Vol. 38 Issue 2 Pg. 121-6 ISSN: 0034-9356 [Print] Spain
Vernacular TitleUtilización de un nuevo inotrópico, enoximone, en cirugía cardíaca.
PMID1678896 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Adrenergic beta-Agonists
  • Cardiotonic Agents
  • Imidazoles
  • Phosphodiesterase Inhibitors
  • Enoximone
Topics
  • Adrenergic beta-Agonists (adverse effects, therapeutic use)
  • Aged
  • Arrhythmias, Cardiac (chemically induced, prevention & control)
  • Cardiac Output, Low (drug therapy, prevention & control)
  • Cardiac Surgical Procedures (adverse effects)
  • Cardiopulmonary Bypass (adverse effects)
  • Cardiotonic Agents (adverse effects, pharmacology, therapeutic use)
  • Diuresis (drug effects)
  • Enoximone
  • Female
  • Humans
  • Imidazoles (pharmacology, therapeutic use)
  • Intraoperative Care
  • Intraoperative Complications (drug therapy)
  • Male
  • Middle Aged
  • Myocardial Contraction (drug effects)
  • Phosphodiesterase Inhibitors (pharmacology, therapeutic use)
  • Preanesthetic Medication

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: