Abstract | OBJECTIVE: This study examined the changes of regional cerebral oxygen saturation (rSO2) by noninvasive near infrared spectrophotometry in neonates with meconium aspiration syndrome (MAS). METHODS: Seventy-three full neonates with MAS were divided into three groups by respiratory symptoms: asymptomatic group (group 1, n=38), common group (group 2, n=28) and severe group (group 3, n=7). Near infrared spectrophotometry was used to measure the cerebral rSO2 on days 1, 3, 5 and 7 after birth. Thirty healthy full-term newborns served as the Control group. RESULTS: The cerebral rSO2 of group 1 decreased significantly compared with that of the Control group between days 1 and 3 (P < 0.05). The cerebral rSO2 of group 2 or group 3 was significantly lower than that of group 1 and the Control group on days 1, 3 and 5 (P < 0.05). The MAS patients with mild hypoxic-ischemic encephalopathy (HIE) had significantly higher brain rSO2 levels than those with medium or severe HIE on days 2, 3 and 5 (P < 0.05). CONCLUSIONS: The cerebral rSO2 decreased in neonates with MAS. The values for rSO2 correlated with the severity of HIE in MAS patients.
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Authors | Zhi-Guang Li, Wen-Fang Ye, Fei-Qiu Wen, Hai-Shu Ding |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 8
Issue 3
Pg. 191-4
(Jun 2006)
ISSN: 1008-8830 [Print] China |
PMID | 16787588
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Brain
(metabolism)
- Female
- Humans
- Hypoxia-Ischemia, Brain
(metabolism)
- Infant, Newborn
- Male
- Meconium Aspiration Syndrome
(metabolism)
- Oxygen
(metabolism)
- Spectroscopy, Near-Infrared
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