Abstract |
This study examined the expression and distribution of BCSG-1 in human breast cancer tissue. IHC revealed that BCSG-1 was primarily seen as a cytosolic protein, weakly staining normal mammary epithelial cells but increased in breast tumour cells. Q-PCR revealed that node negative and positive tumours had similar levels of BCSG-1 transcript and BCSG-1/CK19 ratio. There were significantly higher levels in grade 2 and grade 3 tumours compared to grade 1. Patients with NPI (Nottingham prognostic indicator) < 3.4, had a predicted 80% 15-year survival. After a 10-year follow-up, no significant difference was seen between tumours from patients remaining disease-free and those who died of breast cancer. The levels of BCSG-1 significantly correlated with an associated molecule, transglutaminase-3 (r = 0.307, P < 0.05), and weakly with transglutaminase-7 (r = 0.183). BCSG-1 is increased in breast tumour cells, is negatively associated with tumour grade and significantly correlates with levels of transglutaminase-3.
|
Authors | Tracey A Martin, Kelvin Gomez, Gareth Watkins, Anthony Douglas-Jones, Robert E Mansel, Wen G Jiang |
Journal | Oncology reports
(Oncol Rep)
Vol. 16
Issue 1
Pg. 207-12
(Jul 2006)
ISSN: 1021-335X [Print] Greece |
PMID | 16786148
(Publication Type: Journal Article)
|
Chemical References |
- DNA Primers
- RNA, Messenger
- gamma-Synuclein
- TGM3 protein, human
- Transglutaminases
|
Topics |
- Breast Neoplasms
(genetics)
- DNA Primers
(chemistry)
- Disease-Free Survival
- Female
- Follow-Up Studies
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasm Metastasis
- Prognosis
- RNA, Messenger
(metabolism)
- Time Factors
- Transglutaminases
(biosynthesis)
- Treatment Outcome
- gamma-Synuclein
(biosynthesis)
|