Abstract | BACKGROUND: METHODS: Blood pressure was measured continuously by an intra-arterial catheter and a telemetry system in NAR (n = 8). NAR were set successively for 7 days on a normal (0.45% NaCl), high (8% NaCl), low (0.1% NaCl) and normal salt diet again, to assess salt related response in mean systolic (SBP) and diastolic blood pressure (DBP). 11beta-HSD2activity was assessed by measuring the urinary (THB + 5alpha-THB)/THA ratio with gas chromatography - mass spectrometry. RESULTS: Mean SBP and DBP increased with high salt intake (normal salt vs. high salt: SBP: 114 +/- 1 vs.119 +/- 3 mm Hg, p < 0.01; DBP: 84 +/- 1 vs. 88 +/- 3 mm Hg; n = 8; p < 0.01). Urinary (THB +5alpha-THB)/THA ratio increased during the high- salt period when compared to the normal- salt period (high salt vs. normal salt: 0.52 +/- 0.10 vs. 0.37 +/- 0.07; p = 0.05) indicating decreased 11beta-HSD2activity. CONCLUSION: Analbuminemic Nagase rats express increased blood pressure and reduced 11beta-HSD2 activity in response to a high- salt diet.
|
Authors | Zhenrong Yu, Martin Schumacher, Bernhard Dick, Felix J Frey, Brigitte M Frey, Bruno Vogt |
Journal | Nephron. Physiology
(Nephron Physiol)
Vol. 104
Issue 2
Pg. p81-6
( 2006)
ISSN: 1660-2137 [Electronic] Switzerland |
PMID | 16785748
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2006 S. Karger AG, Basel. |
Chemical References |
- Serum Albumin
- Sodium Chloride, Dietary
- Sodium Chloride
|
Topics |
- Adaptation, Physiological
- Administration, Oral
- Animals
- Blood Pressure
- Dose-Response Relationship, Drug
- Female
- Rats
- Serum Albumin
(deficiency)
- Sodium Chloride
(administration & dosage)
- Sodium Chloride, Dietary
(metabolism)
|