Abstract | AIM: METHODS: RESULTS: cIAP1 expression was constantly high in non-neoplastic pancreatic tissues, in pancreatic intraepithelial neoplasia (PanIN) lesions, as well as in a subset of primary and metastatic pancreatic ductal adenocarcinomas (PDAC), and a preferential cytoplasmatic localisation was observed in the tumour tissues. cIAP1 expression was rare in a cohort of cystic tumours. cIAP2 mRNA levels were significantly higher (2.4 fold) in PDAC than in normal tissues. cIAP2 protein was overexpressed in PDAC, and was detectable in low- and high-grade PanIN lesions. Moreover, cIAP2 was often expressed in pancreatic cystic tumours. cIAP1 and cIAP2 mRNA and protein were detected in all the examined cell lines. Survival analysis revealed a shorter survival in patients with cIAP1/cIAP2-positive tumours. CONCLUSIONS: cIAP1 might contribute to the regulation of the apoptotic process in the normal and in the neoplastic pancreas, depending on its subcellular localisation. Overexpression of cIAP2 is a common and early event in the progression of pancreatic cancer, and could therefore potentially influence the important pathophysiological aspects of PDAC, such as anoikis or chemoresistance.
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Authors | Irene Esposito, Jörg Kleeff, Ivane Abiatari, Xined Shi, Nathalia Giese, Frank Bergmann, Wilfried Roth, Helmut Friess, Peter Schirmacher |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 60
Issue 8
Pg. 885-95
(Aug 2007)
ISSN: 0021-9746 [Print] England |
PMID | 16775116
(Publication Type: Journal Article)
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Chemical References |
- Inhibitor of Apoptosis Proteins
- RNA, Messenger
- RNA, Neoplasm
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Topics |
- Adenocarcinoma
(chemistry, pathology)
- Adult
- Aged
- Carcinoma in Situ
(chemistry, pathology)
- Cell Line, Tumor
- Chronic Disease
- Cysts
(chemistry)
- Cytoplasm
(chemistry, pathology)
- Female
- Gene Expression Regulation, Neoplastic
(genetics)
- Humans
- Immunohistochemistry
(methods)
- Inhibitor of Apoptosis Proteins
(analysis, genetics)
- Male
- Middle Aged
- Pancreas
(chemistry, pathology)
- Pancreatic Neoplasms
(genetics, pathology, secondary)
- Pancreatitis
(genetics, pathology)
- RNA, Messenger
(analysis)
- RNA, Neoplasm
(analysis)
- Survival Analysis
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